Details, Fiction and mif
Details, Fiction and mif
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MIF-two in distinction to MIF seems to absence the necessary CXCR-interacting motifs necessary for activation, and it is actually believed to exert a far more selective motion in activating the tissue-protecting CD74 signaling pathway. Having said that, MIF triggers the CD74/CD44/AMPK receptor signaling pathway, which encourages more info glucose uptake in cardiomyocytes and safeguards the guts during ischemia-reperfusion personal injury (93, ninety four). even further research are necessary to determine the probable of MIF/MIF-2 like a cure technique to guard the center from ischemic personal injury.
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form II cells proliferate and differentiate into style I cells, As a result actively reforming the alveolar epithelium just after damage and advertising alveolar repair (71). style II cells express CD74 on their floor. through acute injury for example viral infection, form I cells launch MIF. Extracellular MIF binds to CD74 on adjacent kind II epithelial cells, activating Akt and ERK pathways, resulting in cell proliferation and differentiation to restore the alveolar barrier (72).
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